Antibodies for Immune Cell Therapy
Antibodies for Immune Cell Therapy Antibodies are critical tools for immune cell therapy development.
Antibodies for Immune Cell Therapy
Immune cell therapy is rapidly emerging as an important alternative for cancer treatment, as well as treatment of autoimmune disease. Also known as adoptive cell therapy or cellular immunotherapy, it supercharges an individual’s immune cells to fight disease.
Antibodies are critical tools for each step of the cellular immunotherapy workflow. They can be used to isolate, activate, and characterize both the cellular input and the final immune cell therapy product. Whether your goal is to isolate and expand TILs or engineer CAR T cells or CAR NK cells, Chemsis has validated antibodies and other quality reagents for each stage of the manufacturing process.
Antibodies for Immune Cell Characterization
Immune cell markers are characteristic proteins expressed in different types of immune cells that enable researchers to distinguish between them. Antibodies are used in techniques such as flow cytometry or IHC to quantify the number of cells of a specific lineage, cell subtype or activation state – a technique called immunophenotyping.
| T Cells | |
| Cell Populations | Markers |
| Hematopoietic Lineage | CD45 |
| All T cells | CD3 |
| CD4+ T cells | CD4 |
| CD8+ T cells | CD8 |
| γ/δ T cells | γ/δ TCR |
| iNKT cells | Vα24Jα18 TCR |
| Naïve T cells | L-selectin/CD62L, CCR7 |
| T regulatory cells (Tregs) | CD25/IL-2Rα |
| NK Cells | |
| Cell Populations | Markers |
| Hematopoietic Lineage | CD45 |
| NK cells | NCAM-1/CD56 |
| NK cells for ADCC | Fc Gamma R III (CD16) |
| Pro-inflammatory NK cells | CD161 |
